Reversion of antibiotic resistance in multidrug-resistant pathogens using non-antibiotic pharmaceutical benzydamine
Liu et al. describe the antibiotic adjuvant effect of the FDA approved drug, benzydamine, for the treatment of infections caused by multidrug-resistant bacteria. Mechanistically, benzydamine dissipates membrane potential in both Gram-positive and Gram-negative bacteria, upregulates the transmembrane...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-11-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02854-z |
| _version_ | 1818900120433852416 |
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| author | Yuan Liu Ziwen Tong Jingru Shi Yuqian Jia Tian Deng Zhiqiang Wang |
| author_facet | Yuan Liu Ziwen Tong Jingru Shi Yuqian Jia Tian Deng Zhiqiang Wang |
| author_sort | Yuan Liu |
| collection | DOAJ |
| description | Liu et al. describe the antibiotic adjuvant effect of the FDA approved drug, benzydamine, for the treatment of infections caused by multidrug-resistant bacteria. Mechanistically, benzydamine dissipates membrane potential in both Gram-positive and Gram-negative bacteria, upregulates the transmembrane proton gradient and promotes the uptake of tetracyclines, accounting for its bactericidal activity. |
| first_indexed | 2024-12-19T19:58:48Z |
| format | Article |
| id | doaj.art-b267cd9c901347399769c556a2740cfb |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-19T19:58:48Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-b267cd9c901347399769c556a2740cfb2022-12-21T20:07:43ZengNature PortfolioCommunications Biology2399-36422021-11-014111210.1038/s42003-021-02854-zReversion of antibiotic resistance in multidrug-resistant pathogens using non-antibiotic pharmaceutical benzydamineYuan Liu0Ziwen Tong1Jingru Shi2Yuqian Jia3Tian Deng4Zhiqiang Wang5College of Veterinary Medicine, Yangzhou UniversityCollege of Veterinary Medicine, Yangzhou UniversityCollege of Veterinary Medicine, Yangzhou UniversityCollege of Veterinary Medicine, Yangzhou UniversityCollege of Veterinary Medicine, Yangzhou UniversityCollege of Veterinary Medicine, Yangzhou UniversityLiu et al. describe the antibiotic adjuvant effect of the FDA approved drug, benzydamine, for the treatment of infections caused by multidrug-resistant bacteria. Mechanistically, benzydamine dissipates membrane potential in both Gram-positive and Gram-negative bacteria, upregulates the transmembrane proton gradient and promotes the uptake of tetracyclines, accounting for its bactericidal activity.https://doi.org/10.1038/s42003-021-02854-z |
| spellingShingle | Yuan Liu Ziwen Tong Jingru Shi Yuqian Jia Tian Deng Zhiqiang Wang Reversion of antibiotic resistance in multidrug-resistant pathogens using non-antibiotic pharmaceutical benzydamine Communications Biology |
| title | Reversion of antibiotic resistance in multidrug-resistant pathogens using non-antibiotic pharmaceutical benzydamine |
| title_full | Reversion of antibiotic resistance in multidrug-resistant pathogens using non-antibiotic pharmaceutical benzydamine |
| title_fullStr | Reversion of antibiotic resistance in multidrug-resistant pathogens using non-antibiotic pharmaceutical benzydamine |
| title_full_unstemmed | Reversion of antibiotic resistance in multidrug-resistant pathogens using non-antibiotic pharmaceutical benzydamine |
| title_short | Reversion of antibiotic resistance in multidrug-resistant pathogens using non-antibiotic pharmaceutical benzydamine |
| title_sort | reversion of antibiotic resistance in multidrug resistant pathogens using non antibiotic pharmaceutical benzydamine |
| url | https://doi.org/10.1038/s42003-021-02854-z |
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