The Nontypeable <named-content content-type="genus-species">Haemophilus influenzae</named-content> Major Adhesin Hia Is a Dual-Function Lectin That Binds to Human-Specific Respiratory Tract Sialic Acid Glycan Receptors

The Nontypeable <named-content content-type="genus-species">Haemophilus influenzae</named-content> Major Adhesin Hia Is a Dual-Function Lectin That Binds to Human-Specific Respiratory Tract Sialic Acid Glycan Receptors

ABSTRACT NTHi is a human-adapted pathogen that colonizes the human respiratory tract. Strains of NTHi express multiple adhesins; however, there is a unique, mutually exclusive relationship between the major adhesins Hia and HMW1 and HMW2 (HMW1/2). Approximately 25% of NTHi strains express Hia, a pha...

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Bibliographic Details
Main Authors: John M. Atack, Christopher J. Day, Jessica Poole, Kenneth L. Brockman, Jamie R. L. Timms, Linda E. Winter, Thomas Haselhorst, Lauren O. Bakaletz, Stephen J. Barenkamp, Michael P. Jennings
Format: Article
Language:English
Published: American Society for Microbiology 2020-12-01
Series:mBio
Subjects:
COPD
NTHi
adhesin
autotransporter proteins
bacterial pathogen
glycan
Online Access:https://journals.asm.org/doi/10.1128/mBio.02714-20

Internet

https://journals.asm.org/doi/10.1128/mBio.02714-20

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