PERK-Mediated Unfolded Protein Response Activation and Oxidative Stress in PARK20 Fibroblasts

PERK-Mediated Unfolded Protein Response Activation and Oxidative Stress in PARK20 Fibroblasts

PARK20, an early onset autosomal recessive parkinsonism is due to mutations in the phosphatidylinositol-phosphatase Synaptojanin 1 (Synj1). We have recently shown that the early endosomal compartments are profoundly altered in PARK20 fibroblasts as well as the endosomal trafficking. Here, we report...

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Bibliographic Details
Main Authors: Giuseppina Amodio, Ornella Moltedo, Dominga Fasano, Lucrezia Zerillo, Marco Oliveti, Paola Di Pietro, Raffaella Faraonio, Paolo Barone, Maria Teresa Pellecchia, Anna De Rosa, Giuseppe De Michele, Elena Polishchuk, Roman Polishchuk, Vincenzo Bonifati, Lucio Nitsch, Giovanna Maria Pierantoni, Maurizio Renna, Chiara Criscuolo, Simona Paladino, Paolo Remondelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Neuroscience
Subjects:
PARK20
PERK (PKR-like endoplasmic reticulum kinase)
oxydative stress
ER stress
Synaptojanin 1
membrane trafficking
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00673/full

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https://www.frontiersin.org/article/10.3389/fnins.2019.00673/full

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