Single-nucleus RNA sequencing reveals the shared mechanisms inducing cognitive impairment between COVID-19 and Alzheimer’s disease

Single-nucleus RNA sequencing reveals the shared mechanisms inducing cognitive impairment between COVID-19 and Alzheimer’s disease

Alzheimer’s disease (AD)-like cognitive impairment, a kind of Neuro-COVID syndrome, is a reported complication of SARS-CoV-2 infection. However, the specific mechanisms remain largely unknown. Here, we integrated single-nucleus RNA-sequencing data to explore the potential shared genes and pathways t...

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Bibliographic Details
Main Authors: Yifan Fu, Zhirong Guo, Yulin Wang, Haonan Zhang, Feifan Zhang, Zihao Xu, Xin Shen, Reiko T. Roppongi, Shaocong Mo, Wenchao Gu, Takahito Nakajima, Yoshito Tsushima
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
single-nucleus RNA sequencing
Alzheimer’s disease
SARS-CoV-2
AD-high-risk scores
cognitive impairment
neuroinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.967356/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.967356/full

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