Single-nucleus RNA sequencing reveals the shared mechanisms inducing cognitive impairment between COVID-19 and Alzheimer’s disease
Alzheimer’s disease (AD)-like cognitive impairment, a kind of Neuro-COVID syndrome, is a reported complication of SARS-CoV-2 infection. However, the specific mechanisms remain largely unknown. Here, we integrated single-nucleus RNA-sequencing data to explore the potential shared genes and pathways t...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.967356/full |
| _version_ | 1798001689110773760 |
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| author | Yifan Fu Yifan Fu Zhirong Guo Yulin Wang Haonan Zhang Feifan Zhang Zihao Xu Xin Shen Reiko T. Roppongi Shaocong Mo Wenchao Gu Wenchao Gu Takahito Nakajima Yoshito Tsushima |
| author_facet | Yifan Fu Yifan Fu Zhirong Guo Yulin Wang Haonan Zhang Feifan Zhang Zihao Xu Xin Shen Reiko T. Roppongi Shaocong Mo Wenchao Gu Wenchao Gu Takahito Nakajima Yoshito Tsushima |
| author_sort | Yifan Fu |
| collection | DOAJ |
| description | Alzheimer’s disease (AD)-like cognitive impairment, a kind of Neuro-COVID syndrome, is a reported complication of SARS-CoV-2 infection. However, the specific mechanisms remain largely unknown. Here, we integrated single-nucleus RNA-sequencing data to explore the potential shared genes and pathways that may lead to cognitive dysfunction in AD and COVID-19. We also constructed ingenuity AD-high-risk scores based on AD-high-risk genes from transcriptomic, proteomic, and Genome-Wide Association Studies (GWAS) data to identify disease-associated cell subtypes and potential targets in COVID-19 patients. We demonstrated that the primary disturbed cell populations were astrocytes and neurons between the above two dis-eases that exhibit cognitive impairment. We identified significant relationships between COVID-19 and AD involving synaptic dysfunction, neuronal damage, and neuroinflammation. Our findings may provide new insight for future studies to identify novel targets for preventive and therapeutic interventions in COVID-19 patients. |
| first_indexed | 2024-04-11T11:41:33Z |
| format | Article |
| id | doaj.art-b26ae9e1ac0147209f4e57cba89f45cf |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T11:41:33Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b26ae9e1ac0147209f4e57cba89f45cf2022-12-22T04:25:50ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-09-011310.3389/fimmu.2022.967356967356Single-nucleus RNA sequencing reveals the shared mechanisms inducing cognitive impairment between COVID-19 and Alzheimer’s diseaseYifan Fu0Yifan Fu1Zhirong Guo2Yulin Wang3Haonan Zhang4Feifan Zhang5Zihao Xu6Xin Shen7Reiko T. Roppongi8Shaocong Mo9Wenchao Gu10Wenchao Gu11Takahito Nakajima12Yoshito Tsushima13School of Biological Science and Medical Engineering, Beihang University, Beijing, ChinaCollege of Clinical, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Obstetrics and Gynecology, Peking University First Hospital, Beijing, ChinaDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, ChinaSchool of Biological Science and Medical Engineering, Beihang University, Beijing, ChinaSchool of Biological Science and Medical Engineering, Beihang University, Beijing, ChinaShanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Digestive Diseases, Huashan Hospital, Fudan University, Shanghai, ChinaGunma University Initiative for Advanced Research, Maebashi, JapanDepartment of Digestive Diseases, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Diagnostic and Interventional Radiology, University of Tsukuba, Ibaraki, JapanDepartment of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, Maebashi, JapanDepartment of Diagnostic and Interventional Radiology, University of Tsukuba, Ibaraki, JapanDepartment of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, Maebashi, JapanAlzheimer’s disease (AD)-like cognitive impairment, a kind of Neuro-COVID syndrome, is a reported complication of SARS-CoV-2 infection. However, the specific mechanisms remain largely unknown. Here, we integrated single-nucleus RNA-sequencing data to explore the potential shared genes and pathways that may lead to cognitive dysfunction in AD and COVID-19. We also constructed ingenuity AD-high-risk scores based on AD-high-risk genes from transcriptomic, proteomic, and Genome-Wide Association Studies (GWAS) data to identify disease-associated cell subtypes and potential targets in COVID-19 patients. We demonstrated that the primary disturbed cell populations were astrocytes and neurons between the above two dis-eases that exhibit cognitive impairment. We identified significant relationships between COVID-19 and AD involving synaptic dysfunction, neuronal damage, and neuroinflammation. Our findings may provide new insight for future studies to identify novel targets for preventive and therapeutic interventions in COVID-19 patients.https://www.frontiersin.org/articles/10.3389/fimmu.2022.967356/fullsingle-nucleus RNA sequencingAlzheimer’s diseaseSARS-CoV-2AD-high-risk scorescognitive impairmentneuroinflammation |
| spellingShingle | Yifan Fu Yifan Fu Zhirong Guo Yulin Wang Haonan Zhang Feifan Zhang Zihao Xu Xin Shen Reiko T. Roppongi Shaocong Mo Wenchao Gu Wenchao Gu Takahito Nakajima Yoshito Tsushima Single-nucleus RNA sequencing reveals the shared mechanisms inducing cognitive impairment between COVID-19 and Alzheimer’s disease Frontiers in Immunology single-nucleus RNA sequencing Alzheimer’s disease SARS-CoV-2 AD-high-risk scores cognitive impairment neuroinflammation |
| title | Single-nucleus RNA sequencing reveals the shared mechanisms inducing cognitive impairment between COVID-19 and Alzheimer’s disease |
| title_full | Single-nucleus RNA sequencing reveals the shared mechanisms inducing cognitive impairment between COVID-19 and Alzheimer’s disease |
| title_fullStr | Single-nucleus RNA sequencing reveals the shared mechanisms inducing cognitive impairment between COVID-19 and Alzheimer’s disease |
| title_full_unstemmed | Single-nucleus RNA sequencing reveals the shared mechanisms inducing cognitive impairment between COVID-19 and Alzheimer’s disease |
| title_short | Single-nucleus RNA sequencing reveals the shared mechanisms inducing cognitive impairment between COVID-19 and Alzheimer’s disease |
| title_sort | single nucleus rna sequencing reveals the shared mechanisms inducing cognitive impairment between covid 19 and alzheimer s disease |
| topic | single-nucleus RNA sequencing Alzheimer’s disease SARS-CoV-2 AD-high-risk scores cognitive impairment neuroinflammation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.967356/full |
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