Epigenomic analysis of formalin-fixed paraffin-embedded samples by CUT&Tag

Abstract For more than a century, formalin-fixed paraffin-embedded (FFPE) sample preparation has been the preferred method for long-term preservation of biological material. However, the use of FFPE samples for epigenomic studies has been difficult because of chromatin damage from long exposure to h...

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Bibliographic Details
Main Authors: Steven Henikoff, Jorja G. Henikoff, Kami Ahmad, Ronald M. Paranal, Derek H. Janssens, Zachary R. Russell, Frank Szulzewsky, Sita Kugel, Eric C. Holland
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41666-z