In situ metabolomics in nephrotoxicity of aristolochic acids based on air flow-assisted desorption electrospray ionization mass spectrometry imaging

In situ metabolomics in nephrotoxicity of aristolochic acids based on air flow-assisted desorption electrospray ionization mass spectrometry imaging

Understanding of the nephrotoxicity induced by drug candidates is vital to drug discovery and development. Herein, an in situ metabolomics method based on air flow-assisted desorption electrospray ionization mass spectrometry imaging (AFADESI-MSI) was established for direct analysis of metabolites i...

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Bibliographic Details
Main Authors: Zhonghua Wang, Bingshu He, Yaqi Liu, Meiling Huo, Wenqing Fu, Chunyan Yang, Jinfeng Wei, Zeper Abliz
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Aristolochic acid
Nephrotoxicity
Mass spectrometry imaging
In situ metabolomics
AFADESI
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383519310718

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http://www.sciencedirect.com/science/article/pii/S2211383519310718

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