Biological constraints on GWAS SNPs at suggestive significance thresholds reveal additional BMI loci

Biological constraints on GWAS SNPs at suggestive significance thresholds reveal additional BMI loci

To uncover novel significant association signals (p<5×10−8), genome-wide association studies (GWAS) requires increasingly larger sample sizes to overcome statistical correction for multiple testing. As an alternative, we aimed to identify associations among suggestive signals (5 × 10−8≤p&...

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Bibliographic Details
Main Authors: Reza K Hammond, Matthew C Pahl, Chun Su, Diana L Cousminer, Michelle E Leonard, Sumei Lu, Claudia A Doege, Yadav Wagley, Kenyaita M Hodge, Chiara Lasconi, Matthew E Johnson, James A Pippin, Kurt D Hankenson, Rudolph L Leibel, Alessandra Chesi, Andrew D Wells, Struan FA Grant
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-01-01
Series:eLife
Subjects:
bioinformatics
GWAS
functional genomics
Capture C
body mass index
waist-hip ratio
Online Access:https://elifesciences.org/articles/62206

Internet

https://elifesciences.org/articles/62206

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