Structural basis for DARC binding in reticulocyte invasion by Plasmodium vivax

Abstract The symptoms of malaria occur during the blood stage of infection, when the parasite replicates within human red blood cells. The human malaria parasite, Plasmodium vivax, selectively invades reticulocytes in a process which requires an interaction between the ectodomain of the human DARC r...

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Bibliographic Details
Main Authors: Re’em Moskovitz, Tossapol Pholcharee, Sophia M. DonVito, Bora Guloglu, Edward Lowe, Franziska Mohring, Robert W. Moon, Matthew K. Higgins
Format: Article
Language:English
Published: Nature Portfolio 2023-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-39357-w