A Gain-of-Function Cleavage of TonEBP by Coronavirus NSP5 to Suppress IFN-β Expression

A Gain-of-Function Cleavage of TonEBP by Coronavirus NSP5 to Suppress IFN-β Expression

Human coronaviruses (HCoVs) modify host proteins to evade the antiviral defense and sustain viral expansion. Here, we report tonicity-responsive enhancer (TonE) binding protein (TonEBP) as a cellular target of HCoVs. TonEBP was cleaved into N-terminal and C-terminal fragments (TonEBP NT and TonEBP C...

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Bibliographic Details
Main Authors: Hyun Park, Sang Min Lee, Su Ji Jeong, Yeong Cheon Kweon, Go Woon Shin, Whi Young Kim, Whaseon Lee-Kwon, Chan Young Park, Hyug Moo Kwon
Format: Article
Language:English
Published: MDPI AG 2024-09-01
Series:Cells
Subjects:
SARS-CoV-2
innate immunity
<i>IFN-β</i> promoter
gain of function
Online Access:https://www.mdpi.com/2073-4409/13/19/1614

Internet

https://www.mdpi.com/2073-4409/13/19/1614

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