Synthesis, Characterization, Crystal Structure and Antimalarial Activity of (2E)-2-(1-{4-[(7-chloroquinolin-4-yl)amino]phenyl} ethylidene)hydrazine Carbothioamide

Synthesis, Characterization, Crystal Structure and Antimalarial Activity of (2E)-2-(1-{4-[(7-chloroquinolin-4-yl)amino]phenyl} ethylidene)hydrazine Carbothioamide

A simple synthesis and study by UV-vis, IR, NMR, ESI-CID-MS2 and X-ray diffraction of ((2E)-2-(1-{4-[(7-chloroquinolin-4-yl)amino]phenyl}ethylidene)hydrazinecarbothioamide is reported. It was tested in vitro against chloroquine-resistant strain (W2) of Plasmodium falciparum, hemozoin (β-hematin) for...

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Bibliographic Details
Main Authors: Yonathan de J. Parra, Rosa Elena Ferrer, Julia Bruno-Colmenarez, Jaime Charris, Gricela Lobo, Neira Gamboa de Domínguez, Philip J. Rosenthal, Jiri Gut
Format: Article
Language:English
Published: Universidade Federal de Mato Grosso do Sul 2017-10-01
Series:Orbital: The Electronic Journal of Chemistry
Subjects:
thiosemicarbazones
antimalarial activity
crystal structure
Online Access:https://periodicos.ufms.br/index.php/orbital/article/view/16457

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https://periodicos.ufms.br/index.php/orbital/article/view/16457

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