Uromodulin retention in thick ascending limb of Henle's loop affects SCD1 in neighboring proximal tubule: renal transcriptome studies in mouse models of uromodulin-associated kidney disease.

Uromodulin retention in thick ascending limb of Henle's loop affects SCD1 in neighboring proximal tubule: renal transcriptome studies in mouse models of uromodulin-associated kidney disease.

Uromodulin-associated kidney disease (UAKD) is a hereditary progressive renal disease which can lead to renal failure and requires renal replacement therapy. UAKD belongs to the endoplasmic reticulum storage diseases due to maturation defect of mutant uromodulin and its retention in the enlarged end...

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Bibliographic Details
Main Authors: Marion Horsch, Johannes Beckers, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabě de Angelis, Birgit Rathkolb, Eckhard Wolf, Bernhard Aigner, Elisabeth Kemter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4237372?pdf=render

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http://europepmc.org/articles/PMC4237372?pdf=render

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