Population pharmacokinetics of voriconazole and initial dosage optimization in patients with talaromycosis

Population pharmacokinetics of voriconazole and initial dosage optimization in patients with talaromycosis

The high variability and unpredictability of the plasma concentration of voriconazole (VRC) pose a major challenge for clinical administration. The aim of this study was to develop a population pharmacokinetics (PPK) model of VRC and identify the factors influencing VRC PPK in patients with talaromy...

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Bibliographic Details
Main Authors: Zhiwen Jiang, Yinyi Wei, Weie Huang, Bingkun Li, Siru Zhou, Liuwei Liao, Tiantian Li, Tianwei Liang, Xiaoshu Yu, Xiuying Li, Changjing Zhou, Cunwei Cao, TaoTao Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
voriconazole
talaromycosis
population pharmacokinetics
dosage optimization
Monte Carlo simulation
C- reactive protein (CRP)
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.982981/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.982981/full

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