Integrative Ligand-Based Pharmacophore Modeling, Virtual Screening, and Molecular Docking Simulation Approaches Identified Potential Lead Compounds against Pancreatic Cancer by Targeting FAK1

Integrative Ligand-Based Pharmacophore Modeling, Virtual Screening, and Molecular Docking Simulation Approaches Identified Potential Lead Compounds against Pancreatic Cancer by Targeting FAK1

Pancreatic cancer is a very deadly disease with a 5-year survival rate, making it one of the leading causes of cancer-related deaths globally. Focal adhesion kinase 1 (FAK1) is a ubiquitously expressed protein in pancreatic cancer. FAK, a tyrosine kinase that is overexpressed in cancer cells, is cru...

Full description

Bibliographic Details
Main Authors: Mohammad Habibur Rahman Molla, Mohammed Othman Aljahdali, Md Afsar Ahmed Sumon, Amer H. Asseri, Hisham N. Altayb, Md. Shafiqul Islam, Ahad Amer Alsaiari, F. A. Dain Md Opo, Nushrat Jahan, Foysal Ahammad, Farhan Mohammad
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Pharmaceuticals
Subjects:
pancreatic cancer
FAK1 protein
ligand-based pharmacophore drug design
purchasable compounds
molecular docking
ADMET
Online Access:https://www.mdpi.com/1424-8247/16/1/120

Internet

https://www.mdpi.com/1424-8247/16/1/120

Similar Items