Parallel fiber to Purkinje cell synaptic impairment in a mouse model of spinocerebellar ataxia type 27

Parallel fiber to Purkinje cell synaptic impairment in a mouse model of spinocerebellar ataxia type 27

Genetically inherited mutations in the fibroblast growth factor 14 (FGF14) gene lead to spinocerebellar ataxia type 27 (SCA27), an autosomal dominant disorder characterized by severe heterogeneous motor and cognitive impairments. Consistently, genetic deletion of Fgf14 in Fgf14-/- mice recapitulates...

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Bibliographic Details
Main Authors: Filippo eTempia, Eriola eHoxha, Giulia eNegro, Musaad A Alshammari, Tahani eAlshammari, Neli ePanova-Elektronova, Fernanda eLaezza
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Ataxia
Synaptic Transmission
Purkinje cell
Glutamatergic Synapse
parallel fiber
Cerebellum.
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00205/full

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http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00205/full

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