The effect of the neutral cytidine protonated analogue pseudoisocytidine on the stability of i-motif structures

Abstract Incorporation of pseudoisocytidine (psC), a neutral analogue of protonated cytidine, in i-motifs has been studied by spectroscopic methods. Our results show that neutral psC:C base pairs can stabilize i-motifs at neutral pH, but the stabilization only occurs when psC:C base pairs are locate...

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Bibliographic Details
Main Authors: B. Mir, X. Solés, C. González, N. Escaja
Format: Article
Language:English
Published: Nature Portfolio 2017-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-02723-y