Salidroside ameliorates severe acute pancreatitis-induced cell injury and pyroptosis by inactivating Akt/NF-κB and caspase-3/GSDME pathways

Salidroside ameliorates severe acute pancreatitis-induced cell injury and pyroptosis by inactivating Akt/NF-κB and caspase-3/GSDME pathways

Our previous studies showed that Salidroside (Sal), a glucoside of the phenylpropanoid tyrosol isolated from Rhodiola rosea L, alleviated severe acute pancreatitis (SAP) by inhibiting inflammation. However, the detailed mechanism remains unclear. Recent evidence has indicated a critical role of Sal...

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Bibliographic Details
Main Authors: Xiaohong Wang, Jing Qian, Yun Meng, Ping Wang, Ruizhi Cheng, Guoxiong Zhou, Shunxing Zhu, Chun Liu
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Heliyon
Subjects:
Salidroside
Severe acute pancreatitis
Pyroptosis
Inflammation
Akt/NF-κB
Caspase-3/GSDME
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023004322

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http://www.sciencedirect.com/science/article/pii/S2405844023004322

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