Whole Exome Sequencing of Multi-Regional Biopsies from Metastatic Lesions to Evaluate Actionable Truncal Mutations Using a Single-Pass Percutaneous Technique

Whole Exome Sequencing of Multi-Regional Biopsies from Metastatic Lesions to Evaluate Actionable Truncal Mutations Using a Single-Pass Percutaneous Technique

We investigate the feasibility of obtaining multiple spatially-separated biopsies from a single lesion to explore intratumor heterogeneity and identify actionable truncal mutations using whole exome sequencing (WES). A single-pass radiologically-guided percutaneous technique was used to obtain four...

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Bibliographic Details
Main Authors: Valerie Heong, Darwin Tay, Shane Ee Goh, Bernard Wee, Tuan Zea Tan, Ross Soo, Brendan Pang, Diana Lim, Anil Gopinathan, Samuel Ow, Cheng Ean Chee, Boon Cher Goh, Soo Chin Lee, Wei Peng Yong, Andrea Wong, Mohamed Feroz Mohd Omar, Richie Soong, David SP Tan
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cancers
Subjects:
intratumor heterogeneity
multiple biopsies
tumor evolution
clonality classification
strategic therapeutic intervention
Online Access:https://www.mdpi.com/2072-6694/12/6/1599

Internet

https://www.mdpi.com/2072-6694/12/6/1599

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