System-wide analyses reveal essential roles of N-terminal protein modification in bacterial membrane integrity

System-wide analyses reveal essential roles of N-terminal protein modification in bacterial membrane integrity

Summary: The removal of the N-terminal formyl group on nascent proteins by peptide deformylase (PDF) is the most prevalent protein modification in bacteria. PDF is a critical target of antibiotic development; however, its role in bacterial physiology remains a long-standing question. This work used...

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Bibliographic Details
Main Authors: Chien-I Yang, Zikun Zhu, Jeffrey J. Jones, Brett Lomenick, Tsui-Fen Chou, Shu-ou Shan
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:iScience
Subjects:
Molecular biology
Bacteriology
Omics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222010288

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http://www.sciencedirect.com/science/article/pii/S2589004222010288

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