Agonist bias and agonist‐dependent antagonism at corticotrophin releasing factor receptors

Abstract The corticotropin‐releasing factor (CRF) receptors represent potential drug targets for the treatment of anxiety, stress, and other disorders. However, it is not known if endogenous CRF receptor agonists display biased signaling, how effective CRF receptor antagonists are at blocking differ...

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Bibliographic Details
Main Authors: Zoe Tasma, Peter Wills, Debbie L. Hay, Christopher S. Walker
Format: Article
Language:English
Published: Wiley 2020-06-01
Series:Pharmacology Research & Perspectives
Subjects:
Online Access:https://doi.org/10.1002/prp2.595