Caveolin-1 Modulates Mechanotransduction Responses to Substrate Stiffness through Actin-Dependent Control of YAP

Caveolin-1 Modulates Mechanotransduction Responses to Substrate Stiffness through Actin-Dependent Control of YAP

Summary: The transcriptional regulator YAP orchestrates many cellular functions, including tissue homeostasis, organ growth control, and tumorigenesis. Mechanical stimuli are a key input to YAP activity, but the mechanisms controlling this regulation remain largely uncharacterized. We show that CAV1...

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Bibliographic Details
Main Authors: Roberto Moreno-Vicente, Dácil María Pavón, Inés Martín-Padura, Mauro Català-Montoro, Alberto Díez-Sánchez, Antonio Quílez-Álvarez, Juan Antonio López, Miguel Sánchez-Álvarez, Jesús Vázquez, Raffaele Strippoli, Miguel A. del Pozo
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718316000

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http://www.sciencedirect.com/science/article/pii/S2211124718316000

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