Synthesis, in vitro and docking studies of 2-substituted 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-4(3H)-one derivatives as agents for the treatment of Alzheimer's disease

Synthesis, in vitro and docking studies of 2-substituted 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-4(3H)-one derivatives as agents for the treatment of Alzheimer's disease

Alzheimer's disease is a chronic neurodegenerative disease, which is characterized mainly by a progressive decrease in intellectual abilities, memory impairment and a change in a person's personality. Unfortunately, there are practically no medicines that act on pathogenesis of Alzheimer&#...

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Bibliographic Details
Main Authors: Alexey S. Chiriapkin, Ivan P. Kodonidi, Dmitry I. Pozdnyakov, Alexander A. Glushko
Format: Article
Language:English
Published: Uralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina 2022-04-01
Series:Chimica Techno Acta
Subjects:
alzheimer's disease
tetrahydrothienopyrimidine
synthesis
molecular docking
ache
acetylcholinesterase
anticholinesterase action
amyloid
medicinal chemistry
Online Access:https://journals.urfu.ru/index.php/chimtech/article/view/5734

Internet

https://journals.urfu.ru/index.php/chimtech/article/view/5734

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