Modulating the polyamine/hypusine axis controls generation of CD8+ tissue-resident memory T cells

Modulating the polyamine/hypusine axis controls generation of CD8+ tissue-resident memory T cells

Glutaminolysis is a hallmark of the activation and metabolic reprogramming of T cells. Isotopic tracer analyses of antigen-activated effector CD8+ T cells revealed that glutamine is the principal carbon source for the biosynthesis of polyamines putrescine, spermidine, and spermine. These metabolites...

Full description

Bibliographic Details
Main Authors: Aya G. Elmarsafawi, Rebecca S. Hesterberg, Mario R. Fernandez, Chunying Yang, Lancia N.F. Darville, Min Liu, John M. Koomen, Otto Phanstiel IV, Reginald Atkins, John E. Mullinax, Shari A. Pilon-Thomas, Frederick L. Locke, Pearlie K. Epling-Burnette, John L. Cleveland
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-09-01
Series:JCI Insight
Subjects:
Immunology
Metabolism
Online Access:https://doi.org/10.1172/jci.insight.169308

Internet

https://doi.org/10.1172/jci.insight.169308

Similar Items