Targeting Transcriptional CDKs 7, 8, and 9 with Anilinopyrimidine Derivatives as Anticancer Agents: Design, Synthesis, Biological Evaluation and In Silico Studies

Targeting Transcriptional CDKs 7, 8, and 9 with Anilinopyrimidine Derivatives as Anticancer Agents: Design, Synthesis, Biological Evaluation and In Silico Studies

Cyclin-dependent kinases (CDKs) are promising targets in chemotherapy. In this study, we report a series of 2-anilinopyrimidine derivatives with CDK inhibitory activity. Twenty-one compounds were synthesized and their CDK inhibitory and cytotoxic activities were evaluated. The representative compoun...

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Bibliographic Details
Main Authors: Razan Eskandrani, Lamees S. Al-Rasheed, Siddique Akber Ansari, Ahmed H. Bakheit, Abdulrahman A. Almehizia, Maha Almutairi, Hamad M. Alkahtani
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Molecules
Subjects:
2-anilinopyrimidine
CDK
antiproliferative activity
molecular docking
Online Access:https://www.mdpi.com/1420-3049/28/11/4271

Internet

https://www.mdpi.com/1420-3049/28/11/4271

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