A Vaccine Based on Kunitz-Type Molecule Confers Protection Against Fasciola hepatica Challenge by Inducing IFN-γ and Antibody Immune Responses Through IL-17A Production

A Vaccine Based on Kunitz-Type Molecule Confers Protection Against Fasciola hepatica Challenge by Inducing IFN-γ and Antibody Immune Responses Through IL-17A Production

Fasciola hepatica is helminth parasite found around the world that causes fasciolosis, a chronic disease affecting mainly cattle, sheep, and occasionally humans. Triclabendazole is the drug of choice to treat this parasite. However, the continuous use of this drug has led to the development of paras...

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Bibliographic Details
Main Authors: Leonardo Silvane, Daiana Pamela Celias, Pablo Alberto Romagnoli, Belkys Angélica Maletto, María Fernanda Sanchez Vallecillo, Laura Silvina Chiapello, Santiago Daniel Palma, Daniel Alberto Allemandi, Rodrigo Eduardo Fabrizio Sanabria, César Iván Pruzzo, Claudia Cristina Motrán, Laura Cervi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
Th17-dependent protection
nanostructure
ascorbyl palmitate
kunitz type molecule
vaccine
Fasciola hepatica
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.02087/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.02087/full

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