A permeability‐ and perfusion‐based PBPK model for improved prediction of concentration‐time profiles
Abstract To improve predictions of concentration‐time (C‐t) profiles of drugs, a new physiologically based pharmacokinetic modeling framework (termed ‘PermQ’) has been developed. This model includes permeability into and out of capillaries, cell membranes, and intracellular lipids. New modeling comp...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-08-01
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| Series: | Clinical and Translational Science |
| Online Access: | https://doi.org/10.1111/cts.13314 |