The chondroitin sulfate moiety mediates thrombomodulin-enhanced adhesion and migration of vascular smooth muscle cells

The chondroitin sulfate moiety mediates thrombomodulin-enhanced adhesion and migration of vascular smooth muscle cells

Abstract Background Thrombomodulin (TM), a transmembrane glycoprotein highly expressed in endothelial cells (ECs), is a potent anticoagulant maintaining circulation homeostasis. Under inflammatory states, TM expression is drastically reduced in ECs while vascular smooth muscle cells (VSMCs) show a r...

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Bibliographic Details
Main Authors: Vincent Chunpeng Pai, I-Chung Lo, Yan wun Huang, I-Ching Tsai, Hui-Pin Cheng, Guey-Yueh Shi, Hua-Lin Wu, Meei Jyh Jiang
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Journal of Biomedical Science
Subjects:
Thrombomodulin
Chondroitin sulfate moiety
Migration
Adhesion
Vascular smooth muscle cells
Online Access:http://link.springer.com/article/10.1186/s12929-018-0415-7

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http://link.springer.com/article/10.1186/s12929-018-0415-7

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