Personalized medicine in the dish to prevent calcium leak associated with short-coupled polymorphic ventricular tachycardia in patient-derived cardiomyocytes

Personalized medicine in the dish to prevent calcium leak associated with short-coupled polymorphic ventricular tachycardia in patient-derived cardiomyocytes

Abstract Background Polymorphic ventricular tachycardia (PMVT) is a rare genetic disease associated with structurally normal hearts which in 8% of cases can lead to sudden cardiac death, typically exercise-induced. We previously showed a link between the RyR2-H29D mutation and a clinical phenotype o...

Full description

Bibliographic Details
Main Authors: Yvonne Sleiman, Steven Reiken, Azzouz Charrabi, Fabrice Jaffré, Leah R. Sittenfeld, Jean-Luc Pasquié, Sarah Colombani, Bruce B. Lerman, Shuibing Chen, Andrew R. Marks, Jim W. Cheung, Todd Evans, Alain Lacampagne, Albano C. Meli
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Stem Cell Research & Therapy
Subjects:
Short-coupled PMVT
Isogenic control
Cardiac ryanodine receptor
hiPSC-derived cardiomyocytes
Drug screening
Calcium handling
Online Access:https://doi.org/10.1186/s13287-023-03502-5

Internet

https://doi.org/10.1186/s13287-023-03502-5

Similar Items