TCRβ clones in muscle tissue share structural features in patients with idiopathic inflammatory myopathy and are associated with disease activity

TCRβ clones in muscle tissue share structural features in patients with idiopathic inflammatory myopathy and are associated with disease activity

ObjectivesTo characterize the T cell receptor (TCRβ) repertoire in peripheral blood and muscle tissues of treatment naïve patients with newly diagnosed idiopathic inflammatory myopathies (IIMs).MethodsHigh throughput RNA sequencing of the TCRβ chain was performed in peripheral blood and muscle tissu...

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Bibliographic Details
Main Authors: Dornatien C. Anang, Hannah A. W. Walter, Johan Lim, Ilse T. G. Niewold, Linda van der Weele, Eleonora Aronica, Filip Eftimov, Joost Raaphorst, Barbera D. C. van Schaik, Antoine H. C. van Kampen, Anneke J. van der Kooi, Niek de Vries
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
myositis
T cells
AIRR seq
T cell receptor (TCR)
adaptive immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1279055/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1279055/full

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