Computational Modeling for Antiarrhythmic Drugs for Atrial Fibrillation According to Genotype

Computational Modeling for Antiarrhythmic Drugs for Atrial Fibrillation According to Genotype

Background: The efficacy of antiarrhythmic drugs (AAD) can vary in patients with atrial fibrillation (AF), and the PITX2 gene affects the responsiveness of AADs. We explored the virtual AAD (V-AAD) responses between wild-type and PITX2+/−-deficient AF conditions by realistic in silico AF modeling.Me...

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Bibliographic Details
Main Authors: Inseok Hwang, Ze Jin, Je-Wook Park, Oh-Seok Kwon, Byounghyun Lim, Myunghee Hong, Min Kim, Hee-Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Boyoung Joung, Moon-Hyoung Lee, Hui-Nam Pak
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Physiology
Subjects:
atrial fibrillation
modeling
antiarrhythmic drugs
PITX2
gene
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.650449/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.650449/full

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