Autoimmune Regulator Deficiency Results in a Decrease in STAT1 Levels in Human Monocytes

Autoimmune Regulator Deficiency Results in a Decrease in STAT1 Levels in Human Monocytes

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare primary immunodeficiency disorder typically caused by biallelic autoimmune regulator (AIRE) mutations that manifests with chronic mucocutaneous candidiasis (CMC) and autoimmunity. Patients with STAT1 gain-of-function (...

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Bibliographic Details
Main Authors: Ofer Zimmerman, Lindsey B. Rosen, Muthulekha Swamydas, Elise M. N. Ferre, Mukil Natarajan, Frank van de Veerdonk, Steven M. Holland, Michail S. Lionakis
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Immunology
Subjects:
STAT1
phosphorylation
chronic mucocutaneous candidiasis
AIRE
APECED
CD14+ monocytes
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00820/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00820/full

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