Modulation of the pharmacokinetics of soluble ACE2 decoy receptors through glycosylation

Modulation of the pharmacokinetics of soluble ACE2 decoy receptors through glycosylation

The Spike of SARS-CoV-2 recognizes a transmembrane protease, angiotensin-converting enzyme 2 (ACE2), on host cells to initiate infection. Soluble derivatives of ACE2, in which Spike affinity is enhanced and the protein is fused to Fc of an immunoglobulin, are potent decoy receptors that reduce disea...

Full description

Bibliographic Details
Main Authors: Savanna Skeeters, Kamal Bagale, Galina Stepanyuk, David Thieker, Aaron Aguhob, Kui K. Chan, Benjamin Dutzar, Sergei Shalygin, Asif Shajahan, Xu Yang, Paul A. DaRosa, Emily Frazier, Maximilian M. Sauer, Lisa Bogatzki, Kelly A. Byrnes-Blake, Yifan Song, Parastoo Azadi, Eric Tarcha, Lianghui Zhang, Erik Procko
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
decoy receptor
sialylation
ACE2
SARS-CoV-2
COVID-19
pharmacokinetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050124001177

Internet

http://www.sciencedirect.com/science/article/pii/S2329050124001177

Similar Items