Chaperonin-Containing TCP1 Subunit 5 Protects Against the Effect of Mer Receptor Tyrosine Kinase Knockdown in Retinal Pigment Epithelial Cells by Interacting With Filamentous Actin and Activating the LIM-Kinase 1/Cofilin Pathway

Chaperonin-Containing TCP1 Subunit 5 Protects Against the Effect of Mer Receptor Tyrosine Kinase Knockdown in Retinal Pigment Epithelial Cells by Interacting With Filamentous Actin and Activating the LIM-Kinase 1/Cofilin Pathway

Retinitis pigmentosa (RP), characterized by the gradual loss of rod and cone photoreceptors that eventually leads to blindness, is the most common inherited retinal disorder, affecting more than 2.5 million people worldwide. However, the underlying pathogenesis of RP remains unclear and there is no...

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Bibliographic Details
Main Authors: Lujia Feng, Haichun Li, Yong Du, Ting Zhang, Yingting Zhu, Zhidong Li, Ling Zhao, Xing Wang, Gongpei Wang, Linbin Zhou, Zhaorong Jiang, Zheng Liu, Zhancong Ou, Yuwen Wen, Yehong Zhuo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Medicine
Subjects:
retinitis pigmentosa
MERTK
CCT5
f-actin
phagocytosis
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.861371/full

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https://www.frontiersin.org/articles/10.3389/fmed.2022.861371/full

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