Inhibition of CREB binding protein-beta-catenin signaling down regulates CD133 expression and activates PP2A-PTEN signaling in tumor initiating liver cancer cells

Inhibition of CREB binding protein-beta-catenin signaling down regulates CD133 expression and activates PP2A-PTEN signaling in tumor initiating liver cancer cells

Abstract Background The WNT-beta-catenin pathway is known to regulate cellular homeostasis during development and tissue regeneration. Activation of WNT signaling increases the stability of cytoplasmic beta-catenin and enhances its nuclear translocation. Nuclear beta-catenin function is regulated by...

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Bibliographic Details
Main Authors: Yuanyuan Tang, Joshua Berlind, Nirmala Mavila
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Cell Communication and Signaling
Subjects:
WNT-beta catenin signaling
Tumor initiating cells
Cancer stem cells
CBP
PTEN
CD133
Online Access:http://link.springer.com/article/10.1186/s12964-018-0222-5

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http://link.springer.com/article/10.1186/s12964-018-0222-5

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