Identification of NAD-RNA species and ADPR-RNA decapping in Archaea

Identification of NAD-RNA species and ADPR-RNA decapping in Archaea

Abstract NAD is a coenzyme central to metabolism that also serves as a 5′-terminal cap for bacterial and eukaryotic transcripts. Thermal degradation of NAD can generate nicotinamide and ADP-ribose (ADPR). Here, we use LC-MS/MS and NAD captureSeq to detect and identify NAD-RNAs in the thermophilic mo...

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Main Authors: José Vicente Gomes-Filho, Ruth Breuer, Hector Gabriel Morales-Filloy, Nadiia Pozhydaieva, Andreas Borst, Nicole Paczia, Jörg Soppa, Katharina Höfer, Andres Jäschke, Lennart Randau
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-43377-x

Internet

https://doi.org/10.1038/s41467-023-43377-x

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