New evidence on α-synuclein and Tau binding to conformation and sequence specific GCFNx01 rich DNA: Relevance to neurological disorders

New evidence on α-synuclein and Tau binding to conformation and sequence specific GCFNx01 rich DNA: Relevance to neurological disorders

Background: Deoxyribonucleic acid (DNA) topology plays a critical role in maintaining the integrity of the genome and cellular functions. Although changes in DNA conformation and structural dynamics in the brain have been associated with various neurological disorders, its precise role in the pathog...

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Bibliographic Details
Main Authors: P Vasudevaraju, Erika Guerrero, Muralidhar L Hegde, T B Collen, Gabrielle B Britton, K S Rao
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2012-01-01
Series:Journal of Pharmacy and Bioallied Sciences
Subjects:
α-Synuclein
Alzheimer′s disease
oligonucleotide-protein interaction
Parkinson′s disease
Tau
Z-DNA
Online Access:http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2012;volume=4;issue=2;spage=112;epage=117;aulast=Vasudevaraju

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http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2012;volume=4;issue=2;spage=112;epage=117;aulast=Vasudevaraju

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