Unlocking the role of lactate: metabolic pathways, signaling, and gene regulation in postmitotic retinal cells
The Warburg effect, which was first described a century ago, asserts that mitotic tumor cells generate higher quantities of lactate. Intriguingly, even in typical physiological circumstances, postmitotic retinal photoreceptor cells also produce elevated levels of lactate. Initially classified as met...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Ophthalmology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fopht.2023.1296624/full |
| _version_ | 1797633018134790144 |
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| author | Raju V. S. Rajala Raju V. S. Rajala Raju V. S. Rajala Raju V. S. Rajala Ammaji Rajala Ammaji Rajala |
| author_facet | Raju V. S. Rajala Raju V. S. Rajala Raju V. S. Rajala Raju V. S. Rajala Ammaji Rajala Ammaji Rajala |
| author_sort | Raju V. S. Rajala |
| collection | DOAJ |
| description | The Warburg effect, which was first described a century ago, asserts that mitotic tumor cells generate higher quantities of lactate. Intriguingly, even in typical physiological circumstances, postmitotic retinal photoreceptor cells also produce elevated levels of lactate. Initially classified as metabolic waste, lactate has since gained recognition as a significant intracellular signaling mediator and extracellular ligand. This current review endeavors to provide a concise overview and discourse on the following topics: the localization of lactate-producing enzymes, the functional significance of these enzymes, the signaling functions of lactate, and its impact on the gene expression of photoreceptors in retinal cells. |
| first_indexed | 2024-03-11T11:44:53Z |
| format | Article |
| id | doaj.art-b2c3c164766048bea34246249e93b3ec |
| institution | Directory Open Access Journal |
| issn | 2674-0826 |
| language | English |
| last_indexed | 2024-03-11T11:44:53Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Ophthalmology |
| spelling | doaj.art-b2c3c164766048bea34246249e93b3ec2023-11-09T15:07:25ZengFrontiers Media S.A.Frontiers in Ophthalmology2674-08262023-11-01310.3389/fopht.2023.12966241296624Unlocking the role of lactate: metabolic pathways, signaling, and gene regulation in postmitotic retinal cellsRaju V. S. Rajala0Raju V. S. Rajala1Raju V. S. Rajala2Raju V. S. Rajala3Ammaji Rajala4Ammaji Rajala5Departments of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United StatesDepartments of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United StatesDepartments of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United StatesDean McGee Eye Institute, Oklahoma City, OK, United StatesDepartments of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United StatesDean McGee Eye Institute, Oklahoma City, OK, United StatesThe Warburg effect, which was first described a century ago, asserts that mitotic tumor cells generate higher quantities of lactate. Intriguingly, even in typical physiological circumstances, postmitotic retinal photoreceptor cells also produce elevated levels of lactate. Initially classified as metabolic waste, lactate has since gained recognition as a significant intracellular signaling mediator and extracellular ligand. This current review endeavors to provide a concise overview and discourse on the following topics: the localization of lactate-producing enzymes, the functional significance of these enzymes, the signaling functions of lactate, and its impact on the gene expression of photoreceptors in retinal cells.https://www.frontiersin.org/articles/10.3389/fopht.2023.1296624/fulllactate dehydrogenaselactateposttranslational modificationsphotoreceptor cellsglycolysisaerobic glycolysis |
| spellingShingle | Raju V. S. Rajala Raju V. S. Rajala Raju V. S. Rajala Raju V. S. Rajala Ammaji Rajala Ammaji Rajala Unlocking the role of lactate: metabolic pathways, signaling, and gene regulation in postmitotic retinal cells Frontiers in Ophthalmology lactate dehydrogenase lactate posttranslational modifications photoreceptor cells glycolysis aerobic glycolysis |
| title | Unlocking the role of lactate: metabolic pathways, signaling, and gene regulation in postmitotic retinal cells |
| title_full | Unlocking the role of lactate: metabolic pathways, signaling, and gene regulation in postmitotic retinal cells |
| title_fullStr | Unlocking the role of lactate: metabolic pathways, signaling, and gene regulation in postmitotic retinal cells |
| title_full_unstemmed | Unlocking the role of lactate: metabolic pathways, signaling, and gene regulation in postmitotic retinal cells |
| title_short | Unlocking the role of lactate: metabolic pathways, signaling, and gene regulation in postmitotic retinal cells |
| title_sort | unlocking the role of lactate metabolic pathways signaling and gene regulation in postmitotic retinal cells |
| topic | lactate dehydrogenase lactate posttranslational modifications photoreceptor cells glycolysis aerobic glycolysis |
| url | https://www.frontiersin.org/articles/10.3389/fopht.2023.1296624/full |
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