VEGF dose controls the coupling of angiogenesis and osteogenesis in engineered bone

Abstract Vascular endothelial growth factor-A (VEGF) physiologically regulates both angiogenesis and osteogenesis, but its application in bone tissue engineering led to contradictory outcomes. A poorly understood aspect is how VEGF dose impacts the coordination between these two processes. Taking ad...

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Bibliographic Details
Main Authors: Andrea Grosso, Alexander Lunger, Maximilian G. Burger, Priscilla S. Briquez, Francesca Mai, Jeffrey A. Hubbell, Dirk J. Schaefer, Andrea Banfi, Nunzia Di Maggio
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:npj Regenerative Medicine
Online Access:https://doi.org/10.1038/s41536-023-00288-1