Enhancing the Anticancer Potential of Targeting Tumor-Associated Metalloenzymes via VEGFR Inhibition by New Triazolo[4,3-<i>a</i>]pyrimidinone Acyclo C-Nucleosides Multitarget Agents

Enhancing the Anticancer Potential of Targeting Tumor-Associated Metalloenzymes via VEGFR Inhibition by New Triazolo[4,3-<i>a</i>]pyrimidinone Acyclo C-Nucleosides Multitarget Agents

The role of metalloenzymes in tumor progression had broadened their application in cancer therapy. Of these, MMPs and CAs are validated druggable targets that share some pivotal signaling pathways. The majority of MMPs or CAs inhibitors are designed as single-target agents. Despite their transient e...

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Bibliographic Details
Main Authors: Mohamed Nabil Abd Al Moaty, El Sayed Helmy El Ashry, Laila Fathy Awad, Nihal Ahmed Ibrahim, Marwa Muhammad Abu-Serie, Assem Barakat, Mezna Saleh Altowyan, Mohamed Teleb
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Molecules
Subjects:
MMP-2
CAII
VEGFR-2
multitarget anticancer agents
1,2,4-triazolo[4,3-<i>a</i>]pyrimidinone acyclo C-nucleosides
Online Access:https://www.mdpi.com/1420-3049/27/8/2422

Internet

https://www.mdpi.com/1420-3049/27/8/2422

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