Small Extracellular Vesicle‐Derived vWF Induces a Positive Feedback Loop between Tumor and Endothelial Cells to Promote Angiogenesis and Metastasis in Hepatocellular Carcinoma

Small Extracellular Vesicle‐Derived vWF Induces a Positive Feedback Loop between Tumor and Endothelial Cells to Promote Angiogenesis and Metastasis in Hepatocellular Carcinoma

Abstract Hepatocellular carcinoma (HCC) is a hypervascular malignancy by which its growth and dissemination are largely driven by the modulation of tumor‐derived small extracellular vesicles (sEVs). Proteomic profiling of circulating sEVs of control individuals and HCC patients identifies von Willib...

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Bibliographic Details
Main Authors: Samuel Wan Ki Wong, Sze Keong Tey, Xiaowen Mao, Hiu Ling Fung, Zhi‐Jie Xiao, Danny Ka Ho Wong, Lung‐Yi Mak, Man‐Fung Yuen, Irene Oi‐Lin Ng, Jing Ping Yun, Yi Gao, Judy Wai Ping Yam
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:Advanced Science
Subjects:
feedback signaling
hepatocellular carcinoma
intercellular communication
small extracellular vesicles
von Willebrand factor
Online Access:https://doi.org/10.1002/advs.202302677

Internet

https://doi.org/10.1002/advs.202302677

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