Suppressing high mobility group box-1 release alleviates morphine tolerance via the adenosine 5’-monophosphate-activated protein kinase/heme oxygenase-1 pathway

Suppressing high mobility group box-1 release alleviates morphine tolerance via the adenosine 5’-monophosphate-activated protein kinase/heme oxygenase-1 pathway

Opioids, such as morphine, are the most potent drugs used to treat pain. Long-term use results in high tolerance to morphine. High mobility group box-1 (HMGB1) has been shown to participate in neuropathic or inflammatory pain, but its role in morphine tolerance is unclear. In this study, we establis...

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Bibliographic Details
Main Authors: Tong-Tong Lin, Chun-Yi Jiang, Lei Sheng, Li Wan, Wen Fan, Jin-Can Li, Xiao-Di Sun, Chen-Jie Xu, Liang Hu, Xue-Feng Wu, Yuan Han, Wen-Tao Liu, Yin-Bing Pan
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2023-01-01
Series:Neural Regeneration Research
Subjects:
adenosine 5′-monophosphate-activated protein kinase; heme oxygenase-1; high mobility group box-1; interleukin-1β; microglia; morphine tolerance; neuroinflammation; neuron; nuclear factor-κb p65; toll-like receptor 4
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=9;spage=2067;epage=2074;aulast=Lin

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=9;spage=2067;epage=2074;aulast=Lin

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