Suppressing high mobility group box-1 release alleviates morphine tolerance via the adenosine 5’-monophosphate-activated protein kinase/heme oxygenase-1 pathway
Opioids, such as morphine, are the most potent drugs used to treat pain. Long-term use results in high tolerance to morphine. High mobility group box-1 (HMGB1) has been shown to participate in neuropathic or inflammatory pain, but its role in morphine tolerance is unclear. In this study, we establis...
Main Authors: | , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2023-01-01
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Series: | Neural Regeneration Research |
Subjects: | |
Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=9;spage=2067;epage=2074;aulast=Lin |