Genetic Adjuvants in Replicating Single-Cycle Adenovirus Vectors Amplify Systemic and Mucosal Immune Responses against HIV-1 Envelope

Most infections occur at mucosal surfaces. Providing a barrier of protection at these surfaces may be a useful strategy to combat the earliest events in infection when there are relatively few pathogens to address. The majority of vaccines are delivered systemically by the intramuscular (IM) route....

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Bibliographic Details
Main Authors: William E. Matchett, Goda Baddage Rakitha Malewana, Haley Mudrick, Michael J. Medlyn, Michael A. Barry
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Vaccines
Subjects:
Online Access:https://www.mdpi.com/2076-393X/8/1/64