Pharmacokinetics and Metabolism of Liposome-Encapsulated 2,4,6-Trihydroxygeranylacetophenone in Rats Using High-Resolution Orbitrap Liquid Chromatography Mass Spectrometry

Pharmacokinetics and Metabolism of Liposome-Encapsulated 2,4,6-Trihydroxygeranylacetophenone in Rats Using High-Resolution Orbitrap Liquid Chromatography Mass Spectrometry

2,4,6-trihydroxy-3-geranylacetophenone (tHGA) is a bioactive compound that shows excellent anti-inflammatory properties. However, its pharmacokinetics and metabolism have yet to be evaluated. In this study, a sensitive LC-HRMS method was developed and validated to quantify tHGA in rat plasma. The me...

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Bibliographic Details
Main Authors: Yamen Alkhateeb, Qais Bashir Jarrar, Faridah Abas, Yaya Rukayadi, Chau Ling Tham, Yuen Kah Hay, Khozirah Shaari
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Molecules
Subjects:
pharmacokinetics
metabolism
trihydroxygeranylacetophenone
liposomes
LC-HRMS method validation
Online Access:https://www.mdpi.com/1420-3049/25/13/3069

Internet

https://www.mdpi.com/1420-3049/25/13/3069

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