The Role of the Lysosomal Cl<sup>−</sup>/H<sup>+</sup> Antiporter ClC-7 in Osteopetrosis and Neurodegeneration

The Role of the Lysosomal Cl<sup>−</sup>/H<sup>+</sup> Antiporter ClC-7 in Osteopetrosis and Neurodegeneration

CLC proteins comprise Cl<sup>−</sup> channels and anion/H<sup>+</sup> antiporters involved in several fundamental physiological processes. ClC-7 is a lysosomal Cl<sup>−</sup>/H<sup>+</sup> antiporter that together with its beta subunit Ostm1 has a crit...

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Bibliographic Details
Main Author: Giovanni Zifarelli
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cells
Subjects:
chloride transport
proton transport
organellar transporter
lysosomal storage disease
osteopetrosis
bone
Online Access:https://www.mdpi.com/2073-4409/11/3/366

Internet

https://www.mdpi.com/2073-4409/11/3/366

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