1,3,4-Oxadiazole <i>N</i>-Mannich Bases: Synthesis, Antimicrobial, and Anti-Proliferative Activities

1,3,4-Oxadiazole <i>N</i>-Mannich Bases: Synthesis, Antimicrobial, and Anti-Proliferative Activities

The reaction of 5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazole-2(3<i>H</i>)-thione <b>3</b> with formaldehyde solution and primary aromatic amines or 1-substituted piperazines, in ethanol at room temperature yielded the corresponding <i>N</i>-Mannich bases 3-arylaminome...

Full description

Bibliographic Details
Main Authors:	Lamya H. Al-Wahaibi, Ahmed A. B. Mohamed, Samar S. Tawfik, Hanan M. Hassan, Ali A. El-Emam
Format:	Article
Language:	English
Published:	MDPI AG 2021-04-01
Series:	Molecules
Subjects:	1,3,4-oxadiazoles <i>N</i>-Mannich bases antimicrobial activity anti-proliferative activity
Online Access:	https://www.mdpi.com/1420-3049/26/8/2110

Similar Items

New oxadiazole derivatives of isonicotinohydrazide in the search for antimicrobial agents: Synthesis and in vitro evaluation
by: Malhotra Manav, et al.
Published: (2012-01-01)

Synthesis and evaluation of antimicrobial activity of novel 1,3,4-oxadiazole derivatives
by: Popat B. Mohite, et al.
Published: (2011-09-01)

Anti-Cancer Activity of Derivatives of 1,3,4-Oxadiazole
by: Teresa Glomb, et al.
Published: (2018-12-01)

Synthesis, characterization and antimicrobial activity of 1,3,4-oxadiazole bearing 1H-benzimidazole derivatives
by: Salahuddin, et al.
Published: (2017-02-01)

Synthesis, in silico analysis and antidepressant activity of 1,3,4-oxadiazole derivatives
by: Banylla Felicity Dkhar Gatphoh, et al.
Published: (2022-03-01)

Research progress on the synthesis and pharmacology of 1,3,4-oxadiazole and 1,2,4-oxadiazole derivatives: a mini review
by: Jing-Jing Wang, et al.
Published: (2022-12-01)

Synthesis of formazans from Mannich base of 5-(4-chlorophenyl amino)-2-mercapto-1,3,4-thiadiazole as antimicrobial agents
by: Pramilla Sah, et al.
Published: (2014-04-01)

Cholyl 1,3,4-oxadiazole hybrid compounds: design, synthesis and antimicrobial assessment
by: Anas J. Rasras, et al.
Published: (2022-05-01)

Ultrasound- and Molecular Sieves-Assisted Synthesis, Molecular Docking and Antifungal Evaluation of 5-(4-(Benzyloxy)-substituted phenyl)-3-((phenylamino)methyl)-1,3,4-oxadiazole-2(3H)-thiones
by: Urja D. Nimbalkar, et al.
Published: (2016-05-01)

In-silico ADME prediction and molecular docking study of novel benzimidazole-1,3,4-oxadiazole derivatives as CYP51 inhibitors for antimicrobial activity
by: Shivanand Kolageri, et al.
Published: (2022-09-01)

Comparative Study of the Synthetic Approaches and Biological Activities of the Bioisosteres of 1,3,4-Oxadiazoles and 1,3,4-Thiadiazoles over the Past Decade
by: Rana M. El-Masry, et al.
Published: (2022-04-01)

Synthesis of Novel 2,5-Disubstituted-1,3,4-thiadiazoles Clubbed 1,2,4-Triazole, 1,3,4-Thiadiazole, 1,3,4-Oxadiazole and/or Schiff Base as Potential Antimicrobial and Antiproliferative Agents
by: Nadjet Rezki, et al.
Published: (2015-09-01)

Synthesis of some novel enzyme inhibitors and antibacterial agents derived from 5-(1-(4-tosyl)piperidin-4-yl)-1,3,4-oxadiazol-2-thiol
by: Almas Sattar, et al.

Synthesis and Antimicrobial Activity of 4-S-Methyl-1,3,4-Oxadiazole Derivatives of Some Natural Amino Acids Bearing Secondary Quaternary Ammonium Salt Moieties
by: Daoudi Sofiane, et al.
Published: (2018-12-01)

Synthesis and Antimicrobial Activity of 4-S-Methyl-1,3,4-Oxadiazole Derivatives of Some Natural Amino Acids Bearing Secondary Quaternary Ammonium Salt Moieties
by: Daoudi Sofiane, et al.
Published: (2018-12-01)

Synthesis and Biological Activity of 1,3,4-Oxadiazoles Used in Medicine and Agriculture
by: Marcin Luczynski, et al.
Published: (2022-04-01)

2-Substituted-3-(5-Substituted-1,3,4-oxadiazol/thiadiazol-2-yl) Thiazolidin-4-one Derivatives: Synthesis, Anticancer, Antimicrobial, and Antioxidant Potential
by: Davinder Kumar, et al.
Published: (2023-05-01)

Synthesis and Antimicrobial Activity of N′-Heteroarylidene-1-adamantylcarbohydrazides and (±)-2-(1-Adamantyl)-4-acetyl-5-[5-(4-substituted phenyl-3-isoxazolyl)]-1,3,4-oxadiazolines
by: Abdul-Malek S. Al-Tamimi, et al.
Published: (2012-03-01)

Synthesis and in vitro antibacterial activity of new oxoethylthio-1,3,4-oxadiazole derivatives
by: Jignesh P. Raval, et al.
Published: (2014-04-01)

Arylation Reactions in the Synthesis of Biologically Important 2,5-Diaryl-1,3,4-Oxadiazoles
by: Monika Olesiejuk, et al.
Published: (2022-08-01)

Synthesis of Some New Heterocyclic Fused Rings Compounds Based on 5-Aryl-1,3,4-Oxadiazole
by: Zahra Mohammed Abbas, et al.
Published: (2017-09-01)

Synthetic Approaches and Pharmacological Activity of 1,3,4-Oxadiazoles: A Review of the Literature from 2000–2012
by: Petrônio Filgueiras de Athayde-Filho, et al.
Published: (2012-08-01)

Synthesis and biological evaluation of 1,2,4-triazoles and 1,3,4-oxadiazoles derivatives linked to 1,4-dihydropyridines scaffold
by: Maghsoud Ziaie, et al.
Published: (2017-12-01)

Antimicrobial activities of pyridinium-tailored pyrazoles bearing 1,3,4-oxadiazole scaffolds
by: Lei Zhou, et al.
Published: (2017-11-01)

Synthesis and Antimicrobial Activity of New Mannich Bases with Piperazine Moiety
by: Sara Janowska, et al.
Published: (2023-07-01)

Synthesis of designed new 1,3,4-oxadiazole functionalized pyrano [2,3-f] chromene derivatives and their antimicrobial activities
by: Kahdr Alatawi, et al.
Published: (2024-10-01)

Fungicidal Activity of a Safe 1,3,4-Oxadiazole Derivative Against <i>Candida albicans</i>
by: Daniella Renata Faria, et al.
Published: (2021-03-01)

Synthesis, characterization and antimicrobial activity of benzodioxane ring containing 1,3,4-oxadiazole derivatives
by: Habibullah Khalilullah, et al.
Published: (2016-11-01)

Semisynthesis and insecticidal activity of some novel fraxinellone-based thioethers containing 1,3,4-oxadiazole moiety
by: Yong Guo, et al.
Published: (2017-01-01)

Synthesis, anticancer evaluation and molecular docking studies of new benzimidazole- 1,3,4-oxadiazole derivatives as human topoisomerase types I poison
by: Ulviye Acar Çevik, et al.
Published: (2020-01-01)

A facile one-pot synthesis of novel 2,5-disubstituted-1,3,4-oxadiazoles under conventional and microwave conditions and evaluation of their in vitro antimicrobial activities
by: Nida N. Farshori, et al.
Published: (2017-05-01)

Crystal structures and Hirshfeld surface analysis of 2-(adamantan-1-yl)-5-(4-fluorophenyl)-1,3,4-oxadiazole and 2-(adamantan-1-yl)-5-(4-chlorophenyl)-1,3,4-oxadiazole
by: Lamya H. Al-Wahaibi, et al.
Published: (2019-05-01)

Synthesis and antimicrobial evaluation of some 2,5 disubstituted 1,3,4-oxadiazole derivatives
by: Elham Jafari, et al.
Published: (2017-01-01)

Synthesis of Novel 1,3,4-Oxadiazole-Derived <i>α</i>-Aminophosphonates/<i>α</i>-Aminophosphonic Acids and Evaluation of Their In Vitro Antiviral Activity against the Avian Coronavirus Infectious Bronchitis Virus
by: Shaima Hkiri, et al.
Published: (2022-12-01)

Synthesis , characterization and antimicrobial activity of shiff and mannich bases of uracil derivatives
by: Hala M . Gareeb Alzahawi
Published: (2016-03-01)

Ultrasound-Assisted Synthesis, Antioxidant Activity and Computational Study of 1,3,4-Oxadiazol-2-amines
by: Hamid Beyzaei, et al.
Published: (2021-03-01)

Synthesis, Characterization and Biological Investigation of Some New Hydroxy – 1,3,4 – Oxadiazole Derivatives
by: Afraa S. S, et al.
Published: (2016-09-01)

Synthesis and antibacterial evaluation of some novel mannich bases of benzimidazole derivatives
by: A. Ahmadi
Published: (2017-01-01)

Synthesis, Computational Studies, Antioxidant and Anti-Inflammatory Bio-Evaluation of 2,5-Disubstituted-1,3,4-Oxadiazole Derivatives
by: Sibghat Mansoor Rana, et al.
Published: (2023-07-01)

Synthesis and Antimicrobial Activity of New 5-(2-Thienyl)-1,2,4-triazoles and 5-(2-Thienyl)-1,3,4-oxadiazoles and Related Derivatives
by: Mohamed A. Al-Omar
Published: (2010-01-01)