Targeting the Notch1 oncogene by miR-139-5p inhibits glioma metastasis and epithelial-mesenchymal transition (EMT)

Targeting the Notch1 oncogene by miR-139-5p inhibits glioma metastasis and epithelial-mesenchymal transition (EMT)

Abstract Background Glioma metastasis, invasion, epithelial-mesenchymal transition (EMT) and chemoresistance indicate poor prognosis. Accumulating evidence reveals that Notch1 is an important factor in tumour progression. However, the role of Notch1 in glioma EMT and associated microRNAs (miRNAs) wi...

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Bibliographic Details
Main Authors: Jianlong Li, Qingbin Li, Lin Lin, Rui Wang, Lingchao Chen, Wenzhong Du, Chuanlu Jiang, Ruiyan Li
Format: Article
Language:English
Published: BMC 2018-08-01
Series:BMC Neurology
Subjects:
miR-139-5p
Notch1
EMT
Glioma
Online Access:http://link.springer.com/article/10.1186/s12883-018-1139-8

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http://link.springer.com/article/10.1186/s12883-018-1139-8

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