Modulation of TCR signalling components occurs prior to positive selection and lineage commitment in iNKT cells

Modulation of TCR signalling components occurs prior to positive selection and lineage commitment in iNKT cells

Abstract iNKT cells play a critical role in controlling the strength and character of adaptive and innate immune responses. Their unique functional characteristics are induced by a transcriptional program initiated by positive selection mediated by CD1d expressed by CD4+CD8+ (double positive, DP) th...

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Bibliographic Details
Main Authors: Xuyen T. Dinh, Dragana Stanley, Letitia D. Smith, Morgane Moreau, Stuart P. Berzins, Adrian Gemiarto, Alan G. Baxter, Margaret A. Jordan
Format: Article
Language:English
Published: Nature Portfolio 2021-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-02885-w

Internet

https://doi.org/10.1038/s41598-021-02885-w

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