mTOR Inhibition Subdues Milk Disorder Caused by Maternal VLDLR Loss

mTOR Inhibition Subdues Milk Disorder Caused by Maternal VLDLR Loss

It is unknown whether and how very-low density lipoprotein receptors (VLDLRs) impact skeletal homeostasis. Here, we report that maternal and offspring VLDLRs play opposite roles in osteoclastogenesis and bone resorption. VLDLR deletion in the offspring augments osteoclast differentiation by enhancin...

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Bibliographic Details
Main Authors: HoangDinh Huynh, Wei Wei, Yihong Wan
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Cell Reports
Subjects:
lactation
osteoclast
bone resorption
maternal
milk
VLDLR
mTOR
inflammation
hair
cholesterol
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717306794

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http://www.sciencedirect.com/science/article/pii/S2211124717306794

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