A mathematical model of immune activation with a unified self-nonself concept

A mathematical model of immune activation with a unified self-nonself concept

The adaptive immune system reacts against pathogenic nonself, whereas it normally remains tolerant to self. The initiation of an immune response requires a critical antigen(Ag)-stimulation and a critical number of Ag-specific T cells. Autoreactive T cells are not completely deleted by thymic selecti...

Full description

Bibliographic Details
Main Authors: Sahamoddin eKhailaie, Fariba eBahrami, Mahyar eJanahmadi, Pedro eMilanez-Almeida, Jochen eHuehn, Michael eMeyer-Hermann
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Immunology
Subjects:
Autoimmunity
Central Tolerance
Peripheral Tolerance
regulatory T cells
Autoreactive T cells
immune activation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00474/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00474/full

Similar Items